{"id":2431,"date":"2025-12-13T00:05:05","date_gmt":"2025-12-13T00:05:05","guid":{"rendered":"https:\/\/thewisdomdev.wpengine.com\/?p=2431"},"modified":"2025-12-16T20:58:37","modified_gmt":"2025-12-16T20:58:37","slug":"wisdom-1-0-study-results-personalized-breast-cancer-screening-is-safe-and-smarter","status":"publish","type":"post","link":"https:\/\/www.thewisdomstudy.org\/wisdom-1-0-study-results-personalized-breast-cancer-screening-is-safe-and-smarter\/","title":{"rendered":"WISDOM 1.0 Study Results: Personalized Breast Cancer Screening is Safe and Smarter"},"content":{"rendered":"\t\t
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A Milestone Moment: WISDOM 1.0 Results Point to a New Future for Breast Cancer Screening<\/span><\/b>\u00a0<\/span><\/p>

This year marks a major milestone for the WISDOM Study\u2014and one made possible by the incredible commitment of our community. The long-awaited results from WISDOM 1.0 were published online December 12, 2025, in the <\/span>Journal of the American Medical Association<\/i><\/a><\/span><\/strong> and presented at the San Antonio Breast Cancer Symposium, the world\u2019s largest conference dedicated solely to breast cancer research. Together, these achievements signal an exciting step forward in how breast cancer screening and prevention may be approached in the future.<\/span>\u00a0<\/span><\/p>

WISDOM launched in 2016 with a bold goal: to determine whether screening tailored to a woman\u2019s individual risk could be as safe\u2014and potentially more effective\u2014than the one-size-fits-all approach based mostly on age. The results are in, and they are encouraging.<\/span>\u00a0<\/span><\/p>

What We Learned<\/span><\/b>\u00a0<\/span><\/p>

WISDOM 1.0 enrolled more than 46,000 women between 2016 and 2023. Over 28,000 participants agreed to randomization, with half assigned to annual mammography and half to a personalized, risk-based screening schedule. The central question was straightforward: could tailoring screening intensity to personal risk be as safe as annual screening?<\/span>\u00a0<\/span><\/p>

The answer was yes. Matching screening to individual risk did <\/span>not<\/span><\/b> increase the rate of advanced cancers. In fact, nearly 90% of participants chose risk-based screening when given the option, signaling a strong preference for an approach grounded in personal health information rather than a calendar date.<\/span>\u00a0<\/span><\/p>

How Personalized Screening Worked<\/span><\/b>\u00a0<\/span><\/p>

Participants in the personalized arm completed a detailed questionnaire using the well-validated Breast Cancer Surveillance Consortium (BCSC) risk calculator. Risk assessment also incorporated genetic testing through Color Health\u2019s Hereditary Cancer Panel<\/a><\/strong><\/em><\/span>, polygenic risk scores, breast density, and other biological and lifestyle factors.<\/span>\u00a0<\/span><\/p>

Based on this information, women were grouped into four risk categories and matched with screening recommendations aligned to their needs:<\/span>\u00a0<\/span><\/p>